Abstract: OBJECTIVE To explore the intervention effect of Aidi injection on blood hypercolktive state of 15 patients with advanced colorectal cancer by means of testing plasma D-dimer’s levels. METHODS Thirty cases with colorectal cancer with abnormal D-dimer values were randomly divided into control group and treatment group, 15 cases in each group, and treated with chemotherapy or Aidi injection combining chemotherapy separately. Their plasma D-dimer concentrations were measured by immunoturbidimetric assay before and after treatment. RESULTS D-dimer concentrations of 10 cases in control group rose, the others reduced. No significant difference was found before and after treatment. D-dimer concentrations of 3 cases in treatment group rose, the others reduced. A significant difference of mean was found before and after treatment(P<0.01). The rate of decline and the deviation values of D-dimer were statistically significant difference between two groups(P<0.05 and P<0.01). CONCLUSION Aidi injection can ameliorate D-dimer concentrations of large intestine patients in blood hypercolktive state. Chemotherapy does not influence the plasma D-dimer concentrations of patients with colorectal cancer.