Abstract: OBJECTIVE In order to provide evidence for the prevention, control and treatment of drug-resistance bacteria, the relationship between the drug-resistance rate of antimicrobial drugs used for Escherichia coli and antibacterial drugs use intensity was analyzed. METHODS Retrospective analysis was used for this study. The carbapenems use intensity and drug-resistance rate of Escherichia coli from January 1, 2013 to December 31, 2017 were collected. Pearson statistical method was used to analyze the relationship between use intensity and drug-resistance rate. RESULTS Levofloxacin, ceftazidime, moxifloxacin, ceftriaxone and piperacillin sulbactam ranked the top five in the use intensity of antibacterial drugs, whose values were 11.46, 3.76, 2.75, 2.21 and 1.95, respectively. The drug-resistance rates of Escherichia coli to imipenem cilastatin, piperacillin tazobactam, ceftitam, furantoin and amikacin were <10%. The drug-resistance rates of ampicillin and cefazolin were >80%. The drug-resistance rates of the other tested drugs were mainly about 50%, showed moderate resistance. There was significant positive correlationship between use intensity of imipenem cilastatin, ceftazidime and gentamicin with their drug-resistance rates to Escherichia coli. CONCLUSION There is a significant correlationship between the drug-resistance rates of Escherichia coli partial antibacterial use intensity. Reasonable control of the antibacterial use intensity is one of the effective ways to improve resistance.