Abstract: OBJECTIVE To explore the role of clinical pharmacists play in promoting the rational use of hepatoprotective drugs. METHODS Through pharmaceutical intervention and special commentary work of specialized clinical pharmacists, we analyzed and compared the rational use of hepatoprotective drugs on chemotherapy patients in medical oncology with April 2015 to March 2016 (before intervention) and April 2016 to March 2017 (after intervention). RESULTS Under the appropriate pharmaceutical intervention, species selection, drug use indications, the period of treatment, drug combination, dosage of hepatoprotective drugs in medical oncology were significantly reduced(P<0.05). CONCLUSION After the intervention of clinical pharmacists, it can significantly improve the reasonable usage rate of hepatoprotective drugs, protect patients' drug safety and effectivity, also can reduce adverse drug reactions and the economic burden of patients.