Abstract: OBJECTIVE To optimize clarification technology conditions of Yanggan Zengmian mixture. METHODS With the indexes of content of ferulic acid and clarity, based on single factor test, orthogonal design was selected to optimize flocculation technology with chitosan dosage, pH, flocculation temperature as factors. To optimize alcohol precipitation process with alcohol concentration, pH, alcohol deposition time as factors. The clarification effect of the two processes was compared under the opitimized conditions. RESULTS The best clarification technology was chitosan flocculation clarification method, the optimized condition was 0.10%, chitosan flocculating agent was added at pH 5.0 and 45℃. CONCLUSION Flocculation clarification method is stable, reliable, short period and lowered production cost, the clarification process can be used for Yanggan Zengmian mixture.