Abstract: OBJECTIVE To explore the mechanism of Xiao’er Jianpi cream(XEJPC) of promoting gastrointestinal motility and curing functional dyspepsia(FD). METHODS Irregular diet, drinking acidified water and fatigue were used to establish experimental model of FD, then observed the general state of the rats, Biological Functional System was used to observe the gastric myoelectric activities, ligatured the pylorus and detected the speed of gastric acid secretion and activity of gastric pepsin, ELISA was used to detect the content of motilin(MTL), gastrin(GAS) and SP in blood. RESULTS The oral group and external application group of XEJPC both could obviously increase the stomach muscle contraction, decrease the gastric acid secretion and increase the activity of gastric pepsin in FD rats and increase the content of MTL, GAS and SP in blood. CONCLUSION XEJPC has the pharmacology effects of curing FD, the mechanism may be related to increasing of stomach muscle contraction, decreasing of gastric acid secretion, increasing activity of gastric pepsin and acceleration of MTL, GAS and SP secretion in blood.