非水电位滴定法测定氢溴酸西酞普兰原料药含量的改进

Optimization of Determination Method of Citalopram Hydrobromide by Non-aqueous Potentiometric Titration

摘要: 目的建立革除汞盐的非水电位滴定法测定氢溴酸西酞普兰原料药的含量。方法采用以冰醋酸-醋酐(1∶5)为溶剂的高氯酸电位滴定法测定氢溴酸西酞普兰原料药的含量。结果成功革除醋酸汞，所得实验结果与原方法的测定结果基本一致。结论建立的方法革除了汞盐试剂，滴定突越明显，方法简便、准确，适于氢溴酸西酞普兰原料药的含量测定。

Abstract: OBJECTIVE To establish a determination method of citalopram hydrobromide by non-aqueous potentiometric titration without using mercurate. METHODS Non-aqueous potentiometric titration was used for assay. Citalopram hydrobromide was dissolved in glacial acetic acid-acetic anhydride(1∶5) instead of mercuric salt. RESULTS The results of the improved method were same with that of the original methods. CONCLUSION The improved method discards mercuric salt and obtain an abrupt change of the titration cruve. It is simple and accurate for the determination of citalopram hydrobromide.