Abstract: OBJECTIVE To detective the development status, hot spots and research trends of m6A methylation.METHODS CNKI and Web of Science core database were used to search the related literatures of m6A methylation from 2013to 2021. CiteSpace 5.8.R3 software was used to analyze the cooperative network of literature authors, co-occurrence, clustering and emergence of keywords, and to visualize the map of knowledge.RESULTS The 438 Chinese and 897 English literatures were selected, and the annual number of literatures showed a rapid growth trend. High level journals mainly focus on English literature. The analysis of the issuing institutions showed that Nanjing Medical University, Zhejiang University and Sun Yat-sen University were important scientific research institutions, which were the main research force. Chuan He and Gu Shiyan were the most prolific author in m6A methylation research field, but they had not yet formed a stable core research team. The keywords analysis of literature showed that the research related to detection technology, regulatory mechanisms and targeted drugs,prognostic risk model, and other related fields.CONCLUSION The research on m6A methylation is in a period of rapid development. It is a hot topic to the sequencing technology, the relationship between the distribution of different regulatory factors and the occurrence and development of diseases. In the future, it will be the development trend in malignant tumors,hepatocellular carcinoma, gastric cancer, colorectal cancer and other fields.