Abstract: OBJECTIVE To observe the water extracts from okra on anti-fatigue effects in mice, to explore anti-fatigue effect mechanism of water extracts from okra. METHODS To discuss the anti-fatigue effects of water extracts from okra through weight loading swimming test on mice; to explore the anti-fatigue mechanism by analysis of serum urea changes, hepatic glycogen and serum lactic acid before and after swimming. RESULTS Compared with the control group, the swimming time was increased significantly(P<0.05) in okra extracts groups, and the production of serum urea and serum lactic acid was decreased(P<0.05 and P<0.01), while there was no significant difference of muscle glycogen. CONCLUSION The anti-fatigue effects of okra extracts was obvious. It may be related to the improved metabolic capacity and enhanced ability stress of mice.