Abstract: OBJECTIVE To provide ideas and directions for more in-depth research on gout in the future by summarizing the related researches of metabonomics in the field of gout in recent years. METHODS The relevant literatures were searched by PubMed, and the applications of metabonomics in purine metabolism, hyperuricemia and gout-related diseases were analyzed and summarized. RESULTS Metabonomics technology was widely used in the discovery of biomarkers, the exploration of pathogenesis and the study of drug mechanism of gout diseases. In addition, the combination of metabolomics technology and other omics technologies had become a new research trend. CONCLUSION Metabonomics technology has become an important tool for the study of gout and other human metabolic diseases, which will further promote gout-related researches in the future.