Abstract: OBJECTIVE To discuss the advance on chemical constituents and pharmacological effects of Siegesbeckiae Herba. METHODS The literatures about chemical constituents and pharmacological effects of Siegesbeckiae Herba were searched, collected and summarized. RESULTS & CONCLUSION The main chemical constituents of Siegesbeckiae Herba consist of diterpenes, sesquiterpenes, flavonoids. The extracts and chemical constituents of Siegesbeckiae Herba have anti-inflammatory and analgesic, anti-allergic and cardiovascular protection biological activities.