Abstract: OBJECTIVE To describe the monograph changes in Zhejiang Province of Processing Chinese Crud Drugs 2015 Edition. METHODS The local habitually used monograph and processing methods, the new monographs and the monographs used new processing methods were introduced in this edition of Zhejiang Province of Processing Chinese Crud Drugs. RESULTS The 2015 Edition had recorded 632 monographs in total, which was much less than the 2005 Edition. CONCLUSION Zhejiang Province of Processing Chinese Crud Drugs 2015 Edition integrates with the Chinese Pharmacopoeia, and improves significantly the quality standards and expands the application of advanced techniques and methods in the standards.