Abstract: OBJECTIVE To analyze the clinical manifestations and the diagnosis treatments of drug fever caused by β-amide antibiotics, and to provide reference for the timely and accurate judgment and anti infective therapy of drug fever. METHODS Collected the case of drug fever caused by β-amide antibiotics in four third-grade class-A hospitas from January 2014 to December 2015, analyzed the drug situation, clinical manifestation, auxiliary examination and so on. RESULTS forty-one cases of drug fever caused by beta lactam antibacterial, the most of drug fever caused by piperacillin hetazobactam sodium, 18 cases (43.9%), followed by ceftriaxone in 6 cases (14.6%), 5 cases of cefodizime (12.1%). Eleven cases with only fever performance (26.8%), the remaining 30 cases accompanied by a variety of clinical manifestations. forty cases recovered to normal after stopping the drug. CONCLUSION Clinical pharmacists should make use of their professional advantages to assist clinicians in the early diagnosis and treatment of drug fever.