Abstract: OBJECTIVE To ensure the safe and rational use of cytotoxic drugs by take a pharmaceutical intervention in the administration of cytotoxic drugs. METHODS The medical staff were trained according to the drug instruction and the related literature content, and the pharmaceutically intervene was taken in the administration of cytotoxic drugs with the help of a information platform. RESULTS Intervention was taken in the rationality of prescription, the order of infusion, the velocity of infusion, the intravenous infusion route and the infusion condition for safe and rational use of cytotoxic drugs. CONCLUSION Pharmacists should actively participate in pharmaceutical intervention in the clinical administration of cytotoxic drugs for the safe and rational usage.