Abstract: OBJECTIVE To investigate the risk factors and analyses of antibiotic resistance of severe craniocerebral trauma patients with pulmonary infection of Acinetobacter baumannii of the department of neurosurgery, so as to provide references for clinical prevention and treatment. METHODS The clinical data of 106 patients of severe craniocerebral trauma patients with pulmonary infection of Acinetobacter baumannii from January 2011 to December 2015 were analyzed to investigate related risk factors, and the antimicrobial susceptibility was analyzed by disk diffusion method. The data were analyzed by SPSS 20.0 software. RESULTS The study showed that history of diabetes, low protein hyperlipidemia, GCS score, ICU hospital days, antibacterial drugs species and medication duration and ventilator assisted ventilation time were the risk factors for pulmonary infection of Acinetobacter baumannii (P<0.01). The antimicrobial susceptibility testing showed that cefoperazone sulbactam (71.34%) was the most active agents against Acinetobacter baumannii, followed by amikacin and imipenem, sensitivity rates respectively were 55.41% and 51.59%. CONCLUSION Many risk factors of pulmonary infection of Acinetobacter baumannii are found in department of neurosurgery of severe craniocerebral trauma patients. In clinical work, the corresponding measures should be taken to prevent or reduce the occurrence of pulmonary infection of Acinetobacter baumannii. Acinetobacter baumannii strains are highly resistant to multiple antibiotics. Cefoperazone sulbactam are still the most active agent against Acinetobacter baumannii, followed by amikacin and imipenem. Therapy should be decided according to the results of susceptibility test.