甘草酸磷脂复合物自乳化制剂处方筛选

Preparation of Glycyrrhizic Acid Phospholipid Complex Self-emulsifying Drug Delivery System

摘要: 目的对甘草酸磷脂复合物自乳化制剂(self-emulsifying drug delivery system，SEDDS)进行处方筛选及制备。方法用溶解性实验，处方配伍实验和伪三元相图等方法进行甘草酸磷脂复合物SEDDS制备研究，优选乳化剂，油相和助乳化剂；确定处方组分比例，考察处方自乳化效率。结果最佳甘草酸磷脂复合物SEDDS处方为Labrafil 1944 cs∶Cremophor EL35∶Transcutol HP =45∶40∶15，处方载药量为27.3%；该处方能形成具有乳光透明乳液，粒度分布均匀。结论该方法可成功制备甘草酸磷脂复合物自乳化制剂。

Abstract: OBJECTIVE To prepare glycyrrhizic acid phopholipid compelx self-emulsifying formulation(SEDDS). METHODS Solubility studies, compatibility study and pseudo-ternary phase diagram were used to study the preparation of glycyrrhizic acid phospholipid complex SEDDS. RESLUTS The optimized formulation of glycyrrhizic acid phospholipid complex self-emulsifying preparation was Labrafil 1944cs∶Cremophor EL35∶Transcutol HP=45∶40∶15, with the drug located 27.3%. The obtained emulsion showed even and nano grade particle size with transparent appearance. CONCLUSION Self-emulsifying drug delivery system for glycyrrhizic acid phospholipid complex has been prepared.