Abstract: Ginsenoside is the main active ingredient of Ginseng Radix et Rhizoma. More than 150 species of monomers have been found and different monomers have different pharmacological activities. Ginsenosides mainly excert anti-tumor, anti-senile dementia and other pharmacological effects. Recent studies showed that ginsenosides had some therapeutic actions on liver diseases such as hepatocellular carcinoma, hepatic fibrosis, liver damage, and liver regeneration and transplantation. The mechanism of ginsenosides on liver diseases is relatively complicated, mainly through its antioxidant and anti-inflammatory action to protect the liver cells and regulate liver function. This article reviewed the recent researches about treatment of liver diseases with ginsenosides and the mechanisms of ginsenosides, to provide the reference for further research.