Abstract: OBJECTIVE Nano mesoporous material MCM-41 was used to improve the solubility of nitrendipine(NDP), and combined with push-pull osmotic pump technology to achieve stable release of drugs. METHODS NDP was loaded into mesoporous pores by the solvent evaporation method to obtain the drug delivery system(NDP-MCM-41). The optimal ratio was selected by the dissolution test in vitro. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXDR) and Fourier transform infrared spectroscopy (FTIR) were used to characterize the existing state of NDP. The optimal formulation of osmotic pump tablets was obtained by in vitro dissolution test. RESULTS the drug presented at an amorphous form in mesoporous structure of MCM41. When the ratio of drug and carrier was 1∶5, the dissolution effect was the best. PEO(10 000) as a suspending agent and PEO(600 000) as a booster were used to prepare the push-pull osmotic pump by direct compression method. The amount of each factor, the weight of the coating and the size of the hole could affect the drug release. CONCLUSION The combination of nano mesoporous materials MCM-41 and push pull osmotic pump technology significantly improved the dissolution rate of nimodipine, avoided the burst release and prolonged the drug efficacy.