Abstract: OBJECTIVE To study the stability of the mixture of dezocine, ketorolac tromethamine and tropisetron hydrochloride in 0.9% sodium chloride infusion stored in the silicone rubber material based analgesia pump reservoir. METHODS The admixture was stored at 4, 25, 35 ℃ separately for 72 h. The changes of pH value, insoluble particles and the relative contents were studied with pH meter, particle analyzer and high performance liquid chromatography. RESULTS No significant changes were found in appearance and pH value of the solution in the silicone rubber material analgesia pump reservoir under 4, 25, 35 ℃ within 72 h. The number of insoluble particles was complied with Chinese Pharmacopoeia requirements. The relative contents of dezocine, ketorolac tromethamine and tropisetron hydrochloride were retained in 96%-102%. CONCLUSION Dezocine, ketorolac tromethamine and tropisetron hydrochloride are stable in 0.9% sodium chloride infusion stored in the silicone rubber material based analgesia pump reservoir within 72 h under 4, 25, 35 ℃.