Abstract: OBJECTIVE To study the pharmacodynamic effect of rosin on mice skin cancer. METHODS Skin cancer mice model was caused by the combination of UVC and DMBA, rosin was meanwhile intervened. The histopathology features of skin dyed HE staining and immunohistochemical staining were observed to explore tumor formation and skin morphological alteration, and CK10 and CK5/6 were examined. RESULTS Rosin treatment had an obvious effect on experimental mice, and decreasing the expression of CK10 and CK5/6 might be one of the possible mechanisms of the therapy. CONCLUSION Rosin has a good effect on skin cancer.