Abstract: OBJECTIVE To investigate the effects of Shugan Tiaozhi Fang on blood lipid levels, liver and kidney function and microcirculation in hyperlipidemia model rats. METHODS The hyperlipidemia rat model was established by high-sugar and fat diets and alcohol-drinking. Two weeks after modeling, rats were given Shugan Tiaozhi Fang(0.66, 1.32, 2.64 g·kg^-1) once a day, each group were given continuous administration for 6 weeks. The general signs of the rats were observe before and after administration. The content of total cholesterol(TC), triglyceride(TG), high density lipoprotein-cholesterol(HDL-C), creatinine(CR), blood urea nitrogen(BUN) and the active of ALT in serum were determined. The content of low density lipoprotein-cholesterol(LDL-C) and atherosclerosis index(AI) were calculated. Microcirculation blood flow was detected by laser Doppler technology. RESULTS Shugan Tiaozhi Fang (0.66, 1.32, 2.64 g·kg^-1) improved the general signs of hyperlipidemia rats, reduced the content of TC, TG, LDL-C and AI(P<0.05 or 0.01), and increased the tail microcirculation blood flow(P<0.01). Shugan Tiaozhi Fang 1.32 g·kg^-1 dose reduced the active of ALT(P<0.05), and 1.32, 2.64g·kg-1 reduced the content of CR(P<0.05). CONCLUSION Shugan Tiaozhi Fang could ameliorate the serum lipid levels, liver and kidney function and microcirculation disorder of rats with hyperlipidemia, suggesting that it is capable of regulating blood lipids, ameliorate the liver and kidney damage and microcirculation microcirculation disorder.