Abstract: OBJECTIVE To anslysis the relationship of heavy metals between all and different parts of traditional She medicine-Melastoma dodecandrum. METHODS Heavy metals were investigated according to Chinese Pharmacopoeia 2010. RESULTS The contents of Pb in all of the 26 batches of samples were >5 mg·kg^-1, the number of samples with the content of Cd which was more than 0.3 mg·kg^-1 was 7, and all of the samples with the contents of As, Hg and Cu were <1, 0.1 and 20 mg·kg^-1 respectively. The results with 10 samples which were researches in different parts were as followers: In roots, the contents of Pb were more than 5 mg·kg^-1, and the contents of Cd in 90% samples were more than 0.3 mg·kg^-1; In stems, the contents of Pb were more than 5 mg·kg^-1 in 5 samples, and the contents of Cd were more than 0.3 mg·kg^-1 in all; In leafs, only one samole, the contents of Pb was more than 5 mg·kg^-1, and the contents of Cd were less than 0.3 mg·kg^-1 in all; In addition, the contents of As, Hg and Cu were up to standard in all of the parts. CONCLUSION Taking heavy metals and harmful as index, using the parts on the ground is better According to the principle of safety.