Abstract: OBJECTIVE To explore the compatible stability of Xiangdan injection and 3 kinds of sugar substitute solvent (fructose injection, invert sugar injection and invert sugar electrolytes injection), and to provide reference for clinical medication of patients with diabetes. METHODS According to the maximum amount of clinical application, Xiangdan injection was prepared with 3 kinds of sugar substitute solvent. The appearance of the compatibility of solution, pH value, insoluble particles, content determination, ultraviolet spectrum and maximum absorption wavelength were measured. RESULTS One group of Xiangdan injection and invert sugar electrolyte injection after the compatibility for 20 min turned turbid. The solution properties, particulate matter, content, UV spectrum and maximum absorption wavelength had no change within 5?h after the compatibility of other solutions, and the pH changed slightly in the normal range. CONCLUSION Xiangdan injection and invert sugar electrolyte injection compatibility for clinical is not suggested. The other solutions are basically stable within 5 h after compatibility. It is suggested to stand the solution for some time after compatibility before infusion to improve transfusion safety.