Abstract: OBJECTIVE To investigate the immune-enhancing effects of shell-broken ganoderma lucidum spore powder. METHODS The immune-enhancing effects were evaluated by ConA-induced mice lymphocyte transformation test, sheep red blood cell-induced delayed-type hypersensitivity (DTH) test (foot volume method), antibodies formation in spleens (modified Jerne’s method), serum hemolysin (blood agglutination method), carbon clearance test, phagocytic function of mice macrophages against cock erythrocytes (in-half body method), NK cell activity test (lactate dehydrogenase method). RESULTS The ConA-induced mice lymphocyte transformation test, DTH test, antibodies formation in spleens test and phagocytic function of mice macrophages against cock erythrocytes test showed positive results. CONCLUSION The ganoderma lucidum spore powder showes good immune-enhancing effects.