Abstract: OBJECTIVE To explore the protective effects of Buyang Huanwu decoction(BYHWD) combined with edaravone(ED) on cerebral ischemia-reperfusion injury in mice. METHODS The middle cerebral artery occlusion/reperfusion model was established by the improved intraluminal filament technique in mice. The mice were randomly divided into sham operation group, model group, BYHWD group, ED group, BYHWD+ED group. The differences of neurologic impairment score were observe on 1st, 3rd and 7th day. The cerebral infarction volume was observed and the cellular apoptosis were compared by TUNEL method on the 7th day. RESULTS Compared with sham operation group, neurological deficit score, cerebral infarction volume and the cellular apoptosis increased significantly in model group(P<0.01). Compared with model group, the neurologic impairment score, cerebral infarction volume and the cellular apoptosis decreased significantly in each treated group(P<0.05). The above indexes of drug combination group were better than those of the single drug grup. CONCLUSION The combination of BYHWD and ED has a protective effect on cerebral ischemia-reperfusion injury, which is superior to the simple drug in inhibiting the cellular apoptosis.