Abstract: OBJECTIVE To observe the effect of black currant seed and Zexie decoction, Crataegi Fructus Combination on compounding hypertension and hyperlipoidemia rats in the influence ofsystolic blood pressure and blood lipid. METHODS Renal hypertensionwere fed high fat forage to set up the model of the rats of compounding renal hypertension and hyperlipoidemia. Using factorial design party and to determine factors and level number. According to factorial design 23, rats were randomly divided into 8 groups, and positive control group and sham operation group were set up. Each group was treated differently. The drugs were given by intragastric administration, at once per day for 8 weeks. SBP, TC, TG, LDL-C, HDL-C was measured to observe the effects of different medicine on the test animals. And pathology observation to the tissue slice of liver, kidney and thoracic aorta was done. RESULTS Separated prescription experiment found that only Zexie decoction had effect of depressurization(P<0.01). Black currant seed and Zexie Decoction, Hawthorn all could significantly reduce TC, TG, LDL-C(P<0.05), significantly increase HDL-C. The most effective group was not been split, which had a good depressurization and lipid-lowering effect, and could ease fatty liver and renal glomerulus arteriosclerosis symptom of compounding hypertension and hyperlipidemia rats, make dissepiment of glomerular arteriole and thickness of aortic media thinningz, and effectually protect liver, kidney and thoracic aorta so on capital organ. CONCLUSION The combinationhas effect of depressurization and adjusting blood lipid, and has better protection for liver, kidney and thoracic aorta.