Abstract: OBJECTIVE To observe the curative effect of treating chronic pelvic inflammatory disease with Pu-yao enema liquid, provide the basis for clinical application. METHODS Choose 184 cases of chronic pelvic inflammatory disease of gynecological clinic in our hospital, according to the random number table method divide them into treatment and control groups(n=92). The control group was treated with oral treatment of gynecologic Qianjin tablets; the treatment group was treated with Pu-yao enema liquid on the basis of the control one. Observed and compared the clinical symptom and improvement of signs of the two groups, assess of treatment effect. RESULTS Remedial groups of patients with uterine tenderness, lower abdomen falls the pain, lumbosacral pain, leucorrhea, adnexal block and other clinical symptoms and signs of improvement rate was significantly higher than that of the control group(P<0.05). After treatment, the two groups of patients with signs score significantly decreased(P<0.05), the improvement of the treatment group was better than that of the control group(P<0.05). the cure rate and total effective rate of the treatment group were respectively 41.30% and 94.57%, significantly higher than the control group’s 22.83% and 80.43%(P<0.05). recurrence rate in treatment group was 3.26%, significantly lower than the control group of 10.87%(P<0.05). CONCLUSION The effect of Pu-yao enema liquid in the assist treatment of chronic pelvic inflammatory disease significantly. It can obviously improve the cure rate, improve the clinical symptoms of patients, and effectively reduce the recurrence rate. It was worthy of clinical research and application of the promotion.