Abstract: OBJECTIVE To investigate the application and feasibility of the PDCA cycle theory combined with information technology in the continuous improvement of human albumin rational use. METHODS PDCA (Plan, Do, Check, and Action) model was applied to establish a management strategy for rational use of human albumin. The components of the management model included implanting control rules of albumin dose and dosage by software, strengthening the surveillance of albumin usage regularly, providing educational program for physician. The data was analysed and compared before and after the strategy executed. RESULTS The consumption of albumin decreased form 57 270 g to 27 200 g, the number of patients using albumin decreased from 567 to 359(a drop of 36.7%) simultaneously, the number of patients that using albumin more than 5 days declined from 211 to 116(a drop of 45.0%). CONCLUSION Management strategy based on PDCA model combined with information technology could make continuous improvement of rational use of albumin.