Abstract: OBJECTIVE To investigate potential protection and mechanism of EGCG on kidney ischemia reperfusion injury. METHODS The model of renal ischemia reperfusion injury was induced by clamping the left renal artery for 45 min and reperfusion for 24 h with removing right kindey in rats. The EGCG group were pretreated with 10, 20, 40, 80 mg·kg^-1 EGCG at 45 min by intraperitoneal injection before modle. The pathlogical change of kidney tissues, the expression of Wnt, β-catenin, p53, p21, MDA, CAT, GPX, SOD, IL-6, IFN-γ and TNF-α were examined in rats to evalute the effect of EGCG in renal ischemia reperfusion injury. RESULTS EGCG can significantly decrease renal injury, pathlogical change and the expression of Wnt, β-catenin, MDA, IL-6, IFN-γ and TNF-α with increasing the expression of CAT, GPX and SOD. CONCLUSION EGCG can protect rats against kidney ischemia-reperfusion injury which is associated with suppressing Wnt/β-catenin/p53 signal pathway mediating inflammation and oxidative stress.