Abstract: OBJECTIVE To explore the effect and potentail mechanism of resveratrol(RSV) on the high glucose-induced the proliferation of glomerular mesangial cell HBZY-1(MCs) cultured under high glucose conditions. METHODS The HBZY-1(MCs) cells at logarithmic growth phase were randomly divided into control group, high glucose group and RSV group. The proliferation of the MCS cell was measured by MTT. The mRNA level of Wnt, β-catenin, Collagen-Ⅳ, TNF-α, IL-6 and MCP-1 were measured by RT-PCR. The expression of TNF-α, IL-6 and MCP-1 were measured by ELISA. The expression of Wnt, β-catenin and Collagen-Ⅳ were measured by Western blotting. RESULTS Compared with the control group, the proliferation rate of HBZY-1 cells , the expression of and protein level of Wnt, β-catenin, Collagen-Ⅳ, TNF-α, IL-6 and MCP-1 were significantly increased(P<0.05). Compared with the high glucose group, the proliferation rate of HBZY-1 cells, the expression of and protein level of Wnt, β-catenin, p-p65, Collagen-Ⅳ, TNF-α, IL-6 and MCP-1 were significantly decreased(P<0.05). CONCLUSION RSV can inhibit the proliferation of HBZY-1 cell by suppressing inflammation and the mechanism may be achieved through attenuating Wnt/β-catenin signal transduction pathway activation.