Abstract: Focal adhesion kinase(FAK) is a non-receptor tyrosine kinase in cell, involved in several cellular signaling pathways. FAK is overexpressed and activated in several tumors, and controls the processes of invasion, metastasis, proliferation, growth and survival in tumor cells through both kinase-dependent and kinase-independent pathways. Therefore, FAK becomes an anti-tumor target and has been investigated widely in the past few years. Several FAK inhibitors are under preclinical research or in the clinical trial, which can suppress the growth and metastasis of certain tumor cells. In this paper, the relationship between FAK and tumor and the research of FAK inhibitors is reviewed.