Abstract: OBJECTIVE To design and synthesis of chalcone isoliquiritigenin compounds, and evaluate its anti-cervical cancer activity. Methods Using Claisen-Schmidt reaction principle, by microwave solid-phase synthesis of 5 target compounds, and structural characterization. SiHa(human cervical squamous cell carcinoma) and HeLa(cervical cancer cells) cells as in vitro model, using MTT method to study the inhibitory activity of the target compounds on the proliferation of cervical cancer cells, promotion of the apoptosis of cervical cancer cells by flow cytometry. Results & conclusion Five chalcone isoliquiritigenin compounds were synthesized and characterized by ¹H-NMR, ¹³C-NMR spectra. The target compound could inhibit the proliferation of cervical cancer cells effectively and promote the apoptosis of cervical cancer cells.