Abstract: OBJECTIVE To establish a method of qualitative and quantitative analysis simultaneously for 10 pesticides residues in Menthae Haplocalycis Herba with SPE and GC-MS using the mode of selected ion monitoring. METHODS The pesticides residues were extracted from samples with acetonitrile, then the extract was purified by SPE column and ready for GC-MS analysis. Internal standard method was used for quantification. RESULTS The 10 pesticides were linear in the concentration range of themselves with correlation coefficients more than 0.99. The recoveries of 10 pesticides were from 73.1% to 112.8% at three spiked levels with RSDs no more than 5%. CONCLUSION The method is simple, feasible and sensitive with accurate results, which can be used for the simultaneous analysis of various pesticides residues in Menthae Haplocalycis Herba.