Abstract: OBJECTIVE to explore the effects and possible mechanism of Juniperus extract(JE) on liver fibrosis. METHODS The liver fibrosis model was induced by CCl4, and JE were administered by gastric perfusion at 25, 50 mg·kg^-1 qd for 6 weeks, at the end of the experiment, the contents of alanine transaminase(ALT), aspartate aminotransferase(AST), superoxide dismutase(SOD), maleic dialdehyde(MDA) and the contents of PINP were measured in liver tissue, the expression of MMP-2 was observed by immunohistochemisty. The pathological changes of liver tissue were examined by HE. RESULTS JE(25, 50 mg·kg^-1) improved the liver function significantly through reducing the level of ALT, AST (P<0.05), and increasing the content of SOD (P<0.05 or 0.01), 50 mg·kg-1 JE significantly reduced the centent of MDA and the expression of MMP-2(P<0.05). CONCLUSION JE may inhibit the liver fibrosis induced by CCl4 by decreasing the oxidative stress, the mechanism possibly involves the inhibition of the expression of MMP-2.