Abstract: OBJECTIVE To investigate the effects of N-trans-feruloyloctopamine from garlic skin on Alzheimer’s disease model rats. METHODS Adopted Aβ_1-40 injected into meynert nuclei basales of rats to establish Alzheimer’s disease model, then the compound was given by i.g. to the Alzheimer’s disease model rats, the activities of acetylcholine, acetylcholine transferase and acetylcholinesterase of all samples were detected, the brain tissues were stained by HE staining, the ultrastructure images of the coronary slides in rat hippocampus were examined by electron microscope observation. RESULTS Compared with the model group, the related indexs had differences significantly in FO group(P<0.05, P<0.01). Pathology showed FO could protect neuron apoptosis caused by toxicity of Aβ. CONCLUSION FO has the good function to prevent and treat Alzheimer's disease on model rats.