Abstract: OBJECTIVE To observe the effects of naringin on neuroinflammation after subarachnoid hemorrhage(SAH) in rats. METHODS Fifty-four male SD rats were randomly divided into sham operation group, SAH group, and naringin group (80 mg·kg^-1). Rats were anesthetized overdose, after the rats were decapitated, the brain edema was detected by dry-wet weight method. Brain samples from the ipsilateral basal cortex were lysated, centrifuged, extract the protein. NF-κB protein was detected by Western blot. Rats were fixed in 4% paraformaldehyde, and then were embedded in paraffin wax. Iba-1 and GFAP were detected by immunofluorescent staining. RESULTS Compared with SAH group, naringin treatment coould significantly decrease brain edema, the expression of NF-κB protein, and inhibit the activity of GFAP and Iba-1(P<0.05). CONCLUSION Naringin has anti-inflammation effect on SAH.