Abstract: OBJECTIVE To improve the method for the synthesis of dapoxetine hydrochloride. METHODS Starting with 3-chloro-1-phenyl-1-propanone, dapoxetine hydrochloride was synthesized via a 5-step chain reaction including reduction, etherification, amination by dimethylamine, separation, and acidification by HCl·EA. RESULTS & CONCLUSION The improved process has the advantages of convenient operation, low cost, high yield, and is suitable for industry.