Abstract: OBJECTIVE To establish a rapid analytical method for determining moisture and linarin content in chrysanthemi indici Flos by near-infrared reflectance (NIR) technique. METHODS The NIR spectroscopy data of 45 batches of samples were collected, the data of moisture and linarin content as reference were obtained by drying method and HPLC, respectively. The quantitative model for both was established by partial least squares (PLS) and verified by unknown samples. RESULTS There is a good correlation between the predicted NIR values and the actual values. The root-mean-square error of cross-validation (RMSECV) of the quantitative calibration model of moisture and linarin was 0.568 and 0.282, respectively. The correlation coefficients R2 was 0.976 1 and 0.955 1, respectively, and the RESP?was both controlled within 10%, which were fully meeting the accuracy requirements of?real time process analysis of TCM manufacturing.?CONCLUSION NIR can achieve rapid determination of moisture and linarin in chrysanthemi indici Flos, which can determinate medicinal materials in storage rapidly and save manpower and material resources.