Abstract: OBJECTIVE To investigate the Liu Wu Yi Pills (651 pills) in treatment of angina pectoris of coronary heart disease (CHD) (qi and yin deficiency and blood stasis syndrome) curative effect and influence on exercise tolerance and quality of life. METHODS Fifty-eight patients met the inclusion criteria of patients with CHD, were randomly divided into treatment group (n=30) and control group(n=28), treatment group adopted CHD based regimen(antiplatelet agents, nitrates drugs, beta blockers, statins and angiotensin converting enzyme inhibitor ACEI) plus Liu Wu Yi Pills (651 pills) in control group, onlyusing the CHD treatment, with 4 weeks for 1 courses of treatment, after the end of treatment were followed up for 1 months. Analysis and comparison of the 2 groups before and after treatment in patients with clinical symptoms such as angina, ECG, angina pectoris and 6 minute walk test and the score of the quality of life index changes; changes after treatment between the 2 groups were followed up 1 month of 6 minute walk test(6MWT) and the score of the quality of life. RESULTS the treatment of angina pectoris group total effective rate was significantly better than that in control group (P<0.05). there was no significant difference between the 2 groups of the total effective rate of ECG. nitroglycerin stopped reduction rate of treatment group was significantly higher than that of the control group (P<0.05). compared with before treatment, 6MWT distance of 2 groups were all significantly increased(P<0.01), and the treatment group increased more significantly(P<0.05), after 1 months of follow-up, the difference was more significant (P<0.01). (6) the treatment group in the "the main clinical syndrome", "associated diseases", with “disease awareness” score was significantly higher than the control group (P<0.05), while the difference between the 2 groups in while the other four dimensions no significant difference (P>0.05), but after 1 months of follow-up, the long-term improvement in the treatment group each dimension were lower than those in the control group significantly (P<0.05). CONCLUSION Liu Wu Yi Pills (651 pills) can improve the CHD patients with symptoms of angina, reduce the amount of nitroglycerin, compared with conventionaltherapy, can significantly improve the CHD patients exercise tolerance and quality of life, is one of the effective and safety treatment of traditional Chinese medicine preparation for the angina pectoris of coronary heart disease (qiyin deficiency and blood stasis syndrome).