Abstract: OBJECTIVE To compare the efficacy and safety of dexmedetomidine and propofol for sedation of preeclampsia parturient in caesarean section. METHODS Ninety preeclampsia parturient scheduled for caesarean section under combined spinal-epidural anesthesia (CSEA) were randomly divided into 3 groups (n=30), dexmedetomidine group, propofol group and control group, corresponding drugs were infused in three groups with predetermined method. mean arterial pressure(MAP), heart rate(HR), oxygen saturation(SpO₂), observer’s assessment of alertness/sedation(OAA/S) score were recorded when the patients entered the operating room (T₀), before local anesthetics were given (T₁), cutting skin (T₂), cleaning the abdominal cavity(T₃), and end the operation(T₄). Apgar score and the adverse events were recorded too. RESULTS MAP, HR and OAA/S T_1-4 in dexmedetomidine group and propofol group were significantly lower than control group (P<0.05). MAP T_1-4, HR T_1,3,4 and OAA/S T₄ in dexmedetomidine group were significantly lower in propofol group (P<0.05).There was no significant differences in Apgar score among three groups. The rate of nausea and vomiting, referred pain and shivering in dexmedetomidine group and propofol group were significantly lower than that in control group (P<0.05). There were no significant differences the rate of hypotension and bradycardia and respiratory depression and restlessness in three groups. CONCLUSION Both the dexmedetomidine and propofol are safe and effective for the sedation of preeclampsia parturient in caesarean section, but the dexmedetomidine can offer conscious sedation and more stable hemodynamic and less adverse events.