Abstract: OBJECTIVE To observe the hypertension of patients with malignant tumor treated by Tyrosine kinase inhibitors(TKI), and to discuss the treatment and nursing measures of the hypertension. METHODS Ninty-seven patients with malignant tumor who were treated with Pazopanib, sorafenib, sunitinib and axitinib from Feb 2011 to Jan 2014 were selected, the hypertension of patients were analyzed according to 2010 Chinese guidelines for the management of hypertension. Then the treatment and nursing measures of the hypertension were given. RESULTS Twenty-nine patients (29.9%) who accepted TKI had hypertension, 6 patients (6.2%) had simple systolic hypertension, 11 patients (11.3%) had hypertension of Grade 1, 12 patients (12.4%) had hypertension of Grade 2, none of the patients had shypertension of Grade 3. The earlist medium time from the initiation of treatment to the occurrence of hypertension was 4.0 days. The blood pressure lowered significantly after the nursing. CONCLUSION Timely antihypertensive drug treatment, etiology inspection, condition monitoring, medication nursing, health education, psychological nursing, diet nursing and nursing intervention measures have an important clinical significance to ensure TKI to treat malignant tumor safely and favorably, all the items above can improve the effect of treatment and quality of life of patients.