Abstract: OBJECTIVE To study the analgesic effects of different extract of Linderae Radix and Vinegar Lindera. METHODS Used pain model induced by acetic acid and dysmenorrheal model, observed the analgesic effects of different doses of Linderae Radix and Vinegar Lindera aqueous extract, alcohol extract, ether extract effect on mice. RESULTS In the experimental of pain model induced by acetic acid, compared with normal control group, high dose aqueous extract, alcohol extract of Linderae Radix and high dose aqueous extract, alcohol extract of Vinegar Lindera could significantly reduce the writhing times of mice. In the experimental of dysmenorrheal model, compared with model group, high dose aqueous extract, alcohol extract of Vinegar Lindera could significantly reduce the writhing times of mice. CONCLUSION The aqueous extract, alcohol extract of Linderae Radix and Vinegar Lindera have analgesic effect, Vinegar Lindera have superior analgesic effect than Lindera.