Abstract: OBJECTIVE To analyze the cholesterol-lowering drugs economics systems analysis to provide reference for clinical rational drug use. METHODS The efficacy of lipid lowering drugs was summarized, accordance the analysis of the cost-effectiveness of the drug, the formulation of the drug selection scheme to provide the theoretical basis for the rational drug use. RESULTS Accordance with the pharmacoeconomic analysis, rosuvastatin calcium in all statin drugs effect price ratio was the highest, followed by rosuvastatin cutting atorvastatin calcium, then to pravastatin sodium tablets, the worst for atorvastatin. However, when the dosage of simvastatin was high, the adverse reactions increased, and the effect of simvastatin sodium was not supported at present. Domestic studies showed that the advantage of domestic drug price was obvious, the cost-effectiveness was better than the imported statins. CONCLUSION The study showed that the efficacy of atorvastatin and other statins is good, the price is relatively low. From the perspective of cost-effectiveness analysis, the first choice is rosuvastatin calcium.