Abstract: OBJECTIVE To evaluate protective effects of the calcium dependent phospholipids binding protein Annexin A2 on spinal cord injury in mice. METHODS model mice of spinal cord transection were divided into Annexin A2 group(A2 group), nerve growth factor group(NGF group), negative control group and sham group. The motor function was assessed before and 1, 2 and 4 weeks after the surgery. Daily survival rate was recorded. At 4 weeks after the surgery, spinal neurons were observed in brain sections stained by HE. RESULTS The daily survival rate in Annexin A2 group was higher than that of the negative control group, but lower than that of the NGF group. At the 4 weeks after spinal cord transection injury, the hind limbs motor function score in Annexin A2 group was greater than that in negative control group(P<0.05), and the amount of neurons was larger than that in negative control group. the restoration of neurons to be normal structures showed more obvious in Annexin A2 group. CONCLUSION Annexin A2 can protect the neurons and recover motor function after spinal injury in mice.