Abstract: OBJECTIVE To obsearve the effect of curculigo and epimedium some compatibility of kidney yang deficiency mice role and Preliminary its mechanism of action. METHODS Under the total dosage being constant, several compatible prescriptions were obtained by uniform design with Curculigo and Epimedium classical proportion 1∶1 as a reference. Their extracts were obtained being by water and alcohol. Mice fed with adenine copy kidney Yang model, while 5 g·kg^-1 dose intragastric administration to each compatibility prescripti-ons, after three weeks administration to mice, body weight, locomotor activity, organ index, plasma pitu-itary adrenocorticotropic hormone (ACTH), cyclic adenosine monophosphate (cAMP) content were taken as indexes, comparing the efficacy of different compatible prescriptions. RESULTS Compared with the model group, after three weeks experiment, in water extract 1∶2 group, water extraction Curculigo group, alcohol extract of 1∶2 and 1∶1 groups, body weight of mice increased significantly(P<0.01); independent activity of water extract 1∶2 groups, water extraction Epimedium groups, alcohol extract 1∶2 was increased significantly in the number of mice(P<0.01); water extraction Epimedium group, alcohol extract 1∶2 and water extract 1∶2 group, viscera index increased more obviously; alcohol extract 1∶2 groups, water extract 2∶1 and 1∶2 group, plasma cAMP vitality of mice were increased significantly(P<0.01), and ACTH were increased significantly(P<0.05 or P<0.01). CONCLUSION The different compatibility prescriptions of Erxian soup, water extract 1∶2 group and alcohol extract 1∶2 group the effect of invigorate the kidney and strengthen yang is most significant.