Abstract: In recent years, Chinese medicines based on topical preparations have made significant progress in the wound therapy. More and more Chinese medicines are used in clinical, and achieve obvious therapuetic effects. The roles of?Chinese medicine in the wound healing process caused increasing attention. In this article, the underlying cellular and molecular mechanism for the therapeutic effects of Chinese medicine in wound treatments and the clinical application of Chinese medicine for?skin wound treatment are reviewed and summarized. The development of?Chinese medicine in the treatment of?skin wound is also prospected.