Abstract: OBJECTIVE to visualizationally analysis the current condition of studies on off-label drug use in children in the last five years, to describe the probable research trends, and to provide the possible research goals in future by using co-word analysis of keywords. METHODS CNKI database and the MEDLINE database were searched respectively in Auguest 2014, using keywords “pediatric” and “off-label drug”. Then the Chinese and English high-frenqency keywords were used to build relation matrix by Excel 2013. Visulazed network was finally drawn in Ucinet 6.2. RESULTS The visualized network, successfully built by Netdraw, reflected the hot topics and current condition in this field in the past five years. CONCLUSION Off-label drug use is very common in children. In China, eyes were cast on off-label drug use in children since the last three years. Reasearchers in abroad paid attention to this field much earlier, and their studies have included different aspects of off-label drug use. Meanwhile, clinical trials of off-label drug use in children are done. For the safety use of drugs in children, standardized management is urgently needed all over the world, and clinical trials of pediatric pharmacology should be done to update the information of drug labels.