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    噻奈普汀与氟西汀对照治疗抑郁症患者的系统评价

    Systematic Review of Tianeptine Versus Fluoxetine in the Treatment of Depression

      摘要
    • 摘要: 目的 系统评价噻奈普汀与氟西汀治疗抑郁症的疗效和安全性。方法 计算机检索中国期刊全文数据库、维普全文数据库、万方数据库、PubMed、Medline、EMBase中关于噻奈普汀与氟西汀治疗抑郁症的随机对照试验(RCT)，对纳入的RCT采用Cochrane系统评价的方法进行评价，采用RevMan 5.0统计软件进行Meta分析。结果 共纳入5项研究，合计942例患者，meta分析结果显示，噻奈普汀组患者有效率OR=1.25，95%CI(0.93，1.66)，P=0.13与氟西汀组比较差异无统计学意义；在不良反应发生率方面，2组比较差异有统计学意义OR=0.53，95%CI(0.36~0.77)，P<0.001。结论 噻奈普汀与氟西汀治疗抑郁症疗效相当，不良反应少。但该结论尚需高质量、设计严谨的RCT进一步证实。

       

      Abstract: OBJECTIVE To evaluate the difference and safety of tianeptine and fluoxetine in the treatment of depression. METHODS Retrieved from CNKI, VIP, Wanfang database, PubMed, Medline and EMBase, RCTs about tianeptine with fluoxetine in treatment of depression were collected and evaluated by Cochrane systematic review. Meta-analysis was carried out by using Rev Man 5.0 software. RESULTS The 5 studies were included, involving 942 patients. Meta-analysis showed that there was no statistical significant on clinical efficacy between tianeptine and fluoxetine OR=1.25, 95%CI(0.93,1.66), P=0.13. The incidence of ADR in both group had significant difference OR=0.53, 95%CI(0.36-0.77), P<0.001. CONCLUSION Tianeptine is as effective as fluoxetine for treatment of depression with fewer side effects. However, high quality and large-scale RCT are required for further study.

       

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