Abstract: OBJECTIVE To explore the effect of supplementation vitamin D on inflammation and intestinal permeability in patients with liver cirrhosis. METHODs One hundred and twenty-four patients with liver cirrhosis were randomly divided into the observed group(n=62) and the control group(n=62). They all accepted the conventional treatment, but the patients in the observed group were given the treatment of calcitriol soft capsules (0.25 μg·d^-1) for 3 months. The difference of the inflammatory indexs (TNF-a, IL-6, IL-8) and intestinal permeability indexs (D-lactic acid, endotoxin, procalcitonin) were compared between the two groups before and after treatment. RESULTS The concentrations of TNF-α, IL-6, IL-8 after treatment were significantly lower than that before treatment in both of the two groups(P<0.05). After treatment, the concentrations of TNF-α, IL-6, IL-8 in the observed group were significantly lower than that in the control group(P<0.05). The concentrations of D-lactic acid, endotoxin, procalcitonin after treatment were significantly lower than that before treatment in both of the two groups(P<0.05). After treatment, the concentrations of D-lactic acid, endotoxin, procalcitonin in the observed group were significantly lower than that in the control group(P<0.05). After treatment, the concentrations of alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, gamma glutamyl transferase and alkaline phosphatase were significantly lower than that before treatment in both of the two groups(P<0.05). CONCLUSION Supplementation vitamin D can improve the inflammatory indexes and intestinal permeability in patients with cirrhosis, but has no significant effect on liver function.