Abstract: Liver disease has become one of the common diseases threatening human health. Carbon tetrachloride (CCl₄) is a common compound for liver toxicity, which can induce liver diseases, such as acute liver injury, liver fibrosis, cirrhosis and liver cancer etc. Currently, the experimental animals with liver injury induced by CCl₄ have been widely used for screening liver protection drugs. Pharmacological researches find that many Chinese medicines have therapeutic effect on the diseases. The research progress of molecular mechanism and intervention of Chinese medicines of liver injury induced by CCl₄ are reviewed in this paper to provide a basis for clarifying the mechanism of liver disease and its prevention and treatment.