Abstract: OBJECTIVE To observe the effect of free highly active antiretroviral therapy(HARRT). METHODS Using a retrospective investigation method and analyzing therapeutic effect of HARRT in Jiaxing. RESULTS ①The CD4⁺T lymphocyte average and increase values of 169 HIV/AIDS cases were both shown a significant uptrend. The average values were from (155.36±99.86)μL^-1 in base line to (360.98±141.09)μL^-1 in the 48 months (b=0.362, F=182.07, P<0.001), and the increase values were from (84.43±81.31)μL^-1 in the 6 months to (242.88±140.23)μL^-1 in the 48 months (b=0.364, F=134.82, P<0.001). ②There was a significant growth of CD4⁺T in each treatment phases of HIV/AIDS who were assigned into ≤200 μL^-1 and >200-350 μL^-1 groups (P<0.01). Furthermore, the CD4⁺T values had shown a line growth trend in ≤200 μL^-1 and >200-350 μL^-1 base line groups, respectively (≤200 μL^-1 group, F=274.36, P<0.001; >200-350 μL^-1 group, F=102.25, P<0.001). Results comparison of groups in each same treatment phases were not significant. ③The virus inhibition ratios viral load (VL)<400 cp·mL^-1 were 68.55% (109/159), 77.36% (123/159), 87.42% (139/159), and the failure rates (VL≥10 000 cp·mL^-1) were 12.58% (20/159), 8.80% (14/159), 3.77% (6/159) when cases were treated with 1, 2, 3 year. ④Drug resistance genes had been detected in 10 of the treatment failure cases. CONCLUSION The national free highly active antiretroviral therapy for 4 years has a remarkable curative effect, it is insufficient yet. Some improvement measures are needed in future.